Fig. 6.

Immunomodulatory effects of ODN and ODN nanoparticles in tumor-bearing nude mice. a Induction of IL-12 expression. For the study, 6–8 week old nude mice bearing K562 tumor were untreated or given 5 mg/kg of various ODN formulations by tail vein injection. IL-12 levels were measured by ELISA, as described in the “MATERIALS AND METHODs” section. b Spleen weights for nude mice (n=5) that were untreated or treated with various ODN formulations or empty liposomes (Tf-LP).