Fig. 6.

A schematic summary of the present study show that high levels of IFN-γ either in the presence of aATC alone under control condition or in the presence of aATC and Th₁ cytokines can induce high levels of IFN-γ-driven chemokines CXCL9 and CXCL10 that may suppress MDSC development and differentiation. On the other hand, in the control condition, high levels of tumor-derived IL-1β and IL-6 may negate the effects of low levels of IFN-γ and IFN-γ-driven chemokines CXCL9 and CXCL10 and may support MDSC development