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. Author manuscript; available in PMC: 2013 Oct 19.
Published in final edited form as: Epilepsia. 2011 Jan 4;52(3):551–561. doi: 10.1111/j.1528-1167.2010.02920.x

Figure 1. LAU-0901 limits kindling epileptogenesis.

Figure 1

(A) LAU-0901 attenuates evoked seizure responses induced by kindling procedure compared with vehicle-treated mice (Racine’s Score). This difference is accentuated when mice are stimulated one week after (rekindling, RK). (B) Number of evoked spikes from each afterdischarge (AD) during kindling and one week after. LAU-0901-treated mice show less evoked spikes associated with short AD duration (C) than vehicle-treated mice at day 4 and RK. (D) Representative hippocampal AD from vehicle and LAU-0901-treated mice at day 4 of kindling. Note the initial high amplitude spikes, observed in vehicle, and the poly-spike profile (dashed box) are abolished and reduced respectively in LAU-0901-treated mice. (E, F) Representative power spectral densities (PSD) in the frequency domain, measured in Hz, at day 4 and RK from treated groups, respectively. LAU-0901 attenuates gamma and delta band frequencies in mice at day 4 and at RK, especially in the specific bands indicated in the inset graphics. (G) Representative spectrogram of AD at day 4 of kindling procedure from LAU-0901- and vehicle-treated mice; + = stimulation. Note that LAU-0901 reduces duration and frequencies above 35 Hz. Values represent averages and ± S.E.M; * = p< 0.0001; ** = p<0.05.