TABLE 3.

Metabolic and endocrine parameters by treatment and salt sensitivity

	Low salt	High salt placebo	High salt fenofibrate
Triglycerides (mg/dl)
Salt-resistant	74.2 ± 34.1	76.6 ± 35.8	56.6 ± 28.3^a,^b
Salt-sensitive	83.9 ± 31.8	82.4 ± 25.6	59.4 ± 18.1^a,^b
All	78.6 ± 32.9	79.1 ± 31.4	57.8 ± 24.1^a,^b

Fasting glucose (mg/dl)
Salt-resistant	92.4 ± 10.4	94.5 ± 12.6	93.3 ± 10.5
Salt-sensitive	95.6 ± 11.4	92.6 ± 10.8	88.8 ± 6.9^a
All	93.8 ± 10.8	93.5 ± 11.6	91.3 ± 9.3

Weight (kg)
Salt-resistant	82.6 ± 17.3	83.0 ± 17.0	83.0 ± 17.4
Salt-sensitive	91.5 ± 27.1	92.5 ± 26.3	92.1 ± 26.5
All	86.6 ± 22.3	87.3 ± 21.9^a	87.1 ± 22.0^a

Urinary sodium (mmol/day)
Salt-resistant	28.0 ± 24.5	187.1 ± 74.5^a	181.8 ± 74.2^a
Salt-sensitive	21.4 ± 13.8	204.9 ± 73.5^a	216.0 ± 70.5^a
All	25.0 ± 20.3	195.1 ± 73.4^a	197.2 ± 73.4^a

Urinary potassium (mmol/day)
Salt-resistant	79.6 ± 16.8	90.2 ± 30.9	101.3 ± 31.5^a
Salt-sensitive	67.5 ± 19.9	96.2 ± 40.8^a	97.9 ± 40.3^a
All	74.1 ± 18.9	92.9 ± 35.2^a	99.8 ± 35.1^a

Urine creatinine (g/day)
Salt-resistant	1.41 ± 0.45	1.33 ± 0.36	1.26 ± 0.44
Salt-sensitive	1.66 ± 0.57	1.50 ± 0.71	1.40 ± 0.62
All	1.53 ± 0.51	1.41 ± 0.55	1.32 ± 0.52^a

Aldosterone (pg/ml)
Salt-resistant	164.7 ± 75.8	76.8 ± 32.7^a	81.2 ± 40.5^a
Salt-sensitive	141.6 ± 59.9	64.6 ± 20.6^a	63.8 ± 19.3^a
All	154.2 ± 68.9	71.3 ± 28.1^a	73.6 ± 33.7^a

PRA (ng Ang l/ml per h)
Salt-resistant	3.7 ± 3.1	0.78 ± 0.60^a	0.67 ± 0.41^a
Salt-sensitive	2.5 ± 1.7	0.71 ± 0.65^a	0.51 ± 0.46^a,^b
All	3.2 ± 2.6	0.75 ± 0.62^a	0.60 ± 0.44^a

Plasma norepinephrine (pg/ml)
Salt-resistant	244.1 ± 83.5	173.8 ± 79.3^a	192.5 ± 112.2^a
Salt-sensitive	260.1 ± 94.5	176.6 ± 93.9^a	176.2 ± 80.0^a
All	251.3 ± 87.5	175.1 ± 84.9^a	185.4 ± 98.3^a

Urine DHPG (μg/day)
Salt-resistant	134.7 ± 118.3	40.1 ± 23.9^a	64.5 ± 57.1^a,^b
Salt-sensitive	85.1 ± 45.8	47.9 ± 31.1^a	43.8 ± 32.9^a
All	112.3 ± 94.9	43.6 ± 27.2^a	55.1 ± 48.1^a

Urine norepinephrine (μg/day)
Salt-resistant	133.1 ± 141.2	33.8 ± 34.0^a	58.4 ± 88.8^a
Salt-sensitive	93.4 ± 117.9	33.2 ± 33.3^a	34.5 ± 46.8^a
All	115.2 ± 130.6	33.5 ± 33.1^a	47.6 ± 72.8^a

Urine epinephrine (μg/day)
Salt-resistant	17.3 ± 35.4	4.1 ± 4.0	8.1 ± 8.4^b
Salt-sensitive	8.3 ± 7.2	6.6 ± 11.3	3.8 ± 3.9^a
All	13.2 ± 26.7	5.2 ± 8.1	6.2 ± 7.0

Urine dopamine (μg/day)
Salt-resistant	560.0 ± 717.1	167.3 ± 113.7^a	234.3 ± 171.9
Salt-sensitive	346.0 ± 249.5	200.9 ± 118.8^a	166.0 ± 129.9^a
All	463.3 ± 559.4	182.5 ± 115.4^a	203.5 ± 115.8^a

Data presented as N or mean ± SD. DHPG, dihydroxylphenylglycol; PRA, plasma renin activity.

P <0.05 versus low salt.

P <0.05 versus high salt placebo.