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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Nat Genet. 2013 Aug 11;45(9):984–994. doi: 10.1038/ng.2711

Figure 3.

Figure 3

SNP-based heritabilities and coheritabilities. (a) For each disorder, SNP-based heritabilities are estimated from univariate analyses of the full data set (dark green) or of sample subsets (red and pink bars). These heritabilities are also estimated from bivariate analyses in which different subsets of the same disorder comprise the two traits (blue). Test of the heterogeneity of estimates, P value for Cochran’s Q: schizophrenia, 0.3; bipolar disorder, 1 × 10−6; major depressive disorder, 4 × 10−3; ADHD, 9 × 10−6; ASD, 0.99; Higgins’ I2: schizophrenia, 21%; bipolar disorder, 86%; major depressive disorder, 71%; ADHD, 91%; ASD, 0%). (b) For comparison, the coheritabilities using the full data sets reported in Figure 1 are shown. (c) As a negative control, estimates of coheritabilities with Crohn’s disease, a disease not expected to be genetically related to psychiatric disorders, are shown. We estimated 95% error bars using ± 1.96 s.e.