Table 1.

Univariate analyses: sample description, SNP-based heritabilities and recurrence risk to first-degree relatives

	Schizophrenia	Bipolar disorder	Major depressive disorder	ASD	ADHD
SNPs (imputed)	915,354	995,971	962,093	982,100	917,066
Cases	9,087	6,704	9,041	3,303	4,163
Controls	12,171	9,031	9,381	3,428a	12,040a
N cohorts	17	11	9	8	8
Primary reference	21	22	23	24,25	26–30
CC (s.e.)	0.41 (0.015)	0.44 (0.021)	0.18 (0.017)	0.31 (0.046)	0.25 (0.020)
Disorder risk for the study-based population (disorder risk, K)b
K	0.01	0.01	0.15	0.01	0.05
$h_{\text{SNP}}^2(\mathrm{s}.\mathrm{e}.)$	0.23 (0.008)	0.25 (0.012)	0.21 (0.021)	0.17 (0.025)	0.28 (0.023)
λ1st-SNP (s.e)	2.10 (0.05)	2.23 (0.08)	1.27 (0.03)	1.75 (0.14)	1.71 (0.07)
λ1st	8.8	9.6	1.5	8.7	3.5
Lower bound for disorder risk (K)
K	0.004	0.007	0.1	0.001	0.03
$h_{\text{SNP}}^2(\mathrm{s}.\mathrm{e}.)$	0.19 (0.007)	0.23 (0.010)	0.19 (0.018)	0.11 (0.017)	0.24 (0.020)
λ1st-SNP (s.e)	2.14 (0.06)	2.25 (0.08)	1.31 (0.03)	1.79 (0.15)	1.77 (0.07)
λ1st	14.4	11.7	1.7	29.4	4.5
Upper bound for disorder risk (K)
K	0.012	0.015	0.2	0.015	0.08
$h_{\text{SNP}}^2(\mathrm{s}.\mathrm{e}.)$	0.24 (0.009)	0.27 (0.013)	0.23 (0.023)	0.19 (0.028)	0.32 (0.026)
λ1st-SNP (s.e)	2.10 (0.05)	2.20 (0.07)	1.24 (0.02)	1.74 (0.13)	1.65 (0.06)
λ1st	8.0	7.7	1.4	7.0	2.8
Heritability estimated from twin/family studies61
h2	0.81	0.75	0.37	0.80	0.75

CC is the SNP-based heritability estimated on case-control scale. $h_{\text{SNP}}^2$ is the SNP-based heritability on liability scale, given assumed K. All estimates of $h_{\text{SNP}}^2$ are highly significantly different from zero. λ_1st-SNP is the recurrence risk to first-degree relatives calculated from $h_{\text{SNP}}^2$ and K. λ_1st is the recurrence risk to first-degree relatives calculated from h² from twin and/or family studies and K.