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. Author manuscript; available in PMC: 2013 Oct 19.
Published in final edited form as: Free Radic Biol Med. 2011 Oct 20;52(2):366–376. doi: 10.1016/j.freeradbiomed.2011.10.440

Fig. 4.

Fig. 4

Glutathione redox (GSH/GSSG) state of the myocardium in the WT and Nrf2−/− mice: Determined the redox state of myocardial (ventricular) glutathione in WT and Nrf2−/− mice at 2 months of age (n=6) under basal and after AES conditions. (A) Under basal conditions, no statistically significant change in GSH was measured in WT and Nrf2−/− groups. Significant decrease in GSH was evident in the Nrf2−/− mice after AES, indicating onset of oxidative stress (*P<0.01). (B) Glutathione redox ratio (GSH/GSSG) was comparable under the basal state, but it was tremendously decreased in Nrf2−/− when compared to WT on AES, suggesting oxidative stress in the Nrf2−/− mice. Values are mean±SD for 6 or more animals in each group.