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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: JAMA Psychiatry. 2013 Jun;70(6):599–607. doi: 10.1001/jamapsychiatry.2013.751

Table 3.

Proportion of Variation of Each DSM-IV Criterion for Major Depression Due to Genetic, Shared Environmental, and Individual-Specific Environmental Factors in Our Best-Fit Multivariate Model and the Proportion of the Heritability Due to the 3 Common Genetic Factors

%
Criteria Total a2 F1 F2 F3 sp Total c2 Total e2
Sad mood 29 14 69 17 0 0 70
Anhedonia 29 17 55 28 0 1 70
Weight/appetite 12 25 17 50 8 5 83
Sleep change 19 11 16 68 5 4 77
Psychomotor 20 70 5 25 0 2 78
Fatigue 36 8 19 25 47 1 62
Worthlessness 29 55 31 7 7 2 69
Concentration 26 57 23 8 12 4 70
Suicidal ideation 27 52 7 30 11 5 68

Abbreviations: a2, additive genetic variance; c2, shared environmental variance; e2, unshared environmental variance; F1, psychomotor/cognitive genetic risk factor; F2, mood genetic risk factor; F3, neurovegetative genetic risk factor; sp, criterion-specific genetic.