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. Author manuscript; available in PMC: 2013 Oct 19.
Published in final edited form as: J Immunol. 2011 Jan 31;186(5):3226–3236. doi: 10.4049/jimmunol.1003587

Figure 1. Diagram illustrating the downstream pathways of IL-6 signaling.

Figure 1

In the classic pathway, binding of the IL-6 to its transmembrane receptor IL-6R induces dimerization of the signal transducing receptor subunit gp130 (A). In the trans-signaling pathway, IL-6 binds a soluble form of IL-6R (sIL-6R). The complex IL-6/sIL-6R complex enables activation of cells expressing solely gp130 (B). A soluble form of gp130 (sgp130) selectively blocks trans-signaling (C).