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. Author manuscript; available in PMC: 2013 Oct 19.
Published in final edited form as: J Immunol. 2011 Jan 31;186(5):3226–3236. doi: 10.4049/jimmunol.1003587

Figure 3. Levels of amniotic fluid (AF) IL-6, sIL-6R, sgp130 and sIL-6R/sgp130 molar ratio in pregnancies complicated by intra-amniotic inflammation (IAI) and preterm premature rupture of the membranes (PPROM).

Figure 3

The following groups were studied: no IAI & intact membrane (n=85); no IAI & PPROM (n=61); IAI & intact membrane (n=46); IAI & PPROM (n=30). The AF IL-6 levels were significantly elevated in women with IAI. IL-6 concentrations were lower in women with IAI & PPROM compared to those with IAI & intact membranes (A). The levels of AF sIL-6R were elevated in women with IAI independent of PPROM (B). Pregnancies complicated by PPROM were characterized by lower AF levels of sgp130 and this phenomenon was observed in both pregnancies complicated or not by IAI (C). The sIL-6R/sgp130 molar ratio was significantly elevated by PPROM and further elevated in the setting of PPROM & IAI (D). All results maintained following correction for GA. Different letters reflects statistically significant differences among groups. Thick line represents the median value for the group. Data presented in logarithmic format. Data were analyzed by two-way ANOVA.