Table II.
Demographic, clinical, laboratory and outcome characteristics of with symptoms of preterm labor or PPROM who provided AF samples for sgp130, sIL-6R and IL-6 levels.
| Variable | Rule out infection amniocenteses (n = 222) | ||||
|---|---|---|---|---|---|
| no IAI & intact n = 85 |
no IAI & PPROM n = 61 |
yes IAI & intact n = 46 |
yes IAI & PPROM n = 30 |
P value | |
| Clinical and outcome characteristics at amniocentesis and at delivery | |||||
| Maternal age, years, † | 25 [20 – 32] | 30 [26 – 33] | 24 [21 –- 32] | 33 [25 – 38] | <0.001 |
| Parity † | 1 [0 – 1] | 1 [0 – 2] | 0 [0 – 1] | 1 [0 – 3] | 0.030 |
| Gravidity † | 2 [1 – 3] | 3 [1 – 4] | 2 [1 – 3] | 2 [2 – 5] | 0.365 |
| History of preterm birth ‡ | 21 (25%) | 16 (26%) | 11 (24%) | 7 (23%) | 0.989 |
| GA at amniocentesis, weeks † | 28 [25 – 32] | 30 [28 – 32] | 26 [24 – 29] | 28 [26 – 31] | <0.001 |
| Expectant management ‡ | 72 (87%) | 42 (69%) | 16 (36%) | 10 (33%) | <0.001 |
| GA at delivery, weeks † | 33 [28 – 38] | 32 [30 – 33] | 26 [24 – 29] | 29 [27 – 32] | <0.001 |
| Amniocentesis-delivery interval, hours† | 428 [52 – 1,379] | 107 [31 – 223] | 6 [4 – 11] | 18 [7 – 69] | <0.001 |
| Amniocentesis-delivery < 7 days | 33 (39%) | 37 (61%) | 43 (93%) | 26 (87%) | <0.001 |
| Birthweight, grams † | 2,210 [1,285 –3,060] | 1,820 [1,430 –2,126] | 955 [731 – 1,246] | 1,350 [1,000 –1,710] | <0.001 |
| AF laboratory test results | |||||
| Glucose, mg/dL † | 30 [22 – 39] | 28 [21 – 40] | 3 [2 – 13] | 8 [2 – 18] | <0.001 |
| LDH activity, U/L † | 168 [126 – 236] | 150 [105 – 257] | 924 [541 – 2,083] | 639 [424 – 1,118] | <0.001 |
| WBC count, cells/mm3 † | 3 [1 – 7] | 8 [2 – 22] | 715 [194 – 1,445] | 687 [52 – 2,380] | <0.001 |
| Positive Gram stain ‡ | 0 (0%) | 4 (7%) | 8 (57%) | 11 (37%) | <0.001 |
| Positive cultures ‡ | 1 (1%) | 14 (23%) | 30 (65%) | 22 (73%) | <0.001 |
| Placental histology results | n=59 | n=60 | n=46 | n=30 | |
| Chorionic plate inflammation, stage † | 1 [0 – 2] | 1 [0 – 3] | 3 [3 – 3] | 3 [2 – 3] | <0.001 |
| Amnionitis, grade † | 0 [0 – 0] | 0 [0 – 2] | 3 [2 – 4] | 3 [2 – 3] | <0.001 |
| Chorio-deciduitis, grade † | 1 [0 – 3] | 2 [0 – 3] | 3 [3 – 4] | 3 [2 – 4] | <0.001 |
| Funisitis, grade † | 0 [0 – 0] | 0 [0 – 2] | 3 [0 – 4] | 2 [0 – 4] | <0.001 |
†
Data presented as median [interquartile range] and analyzed by Kruskal-Wallis ANOVA on Ranks.
‡
Data presented as n (%) and analyzed by Chi square test.
Abbreviations: IAI, intra-amniotic inflammation; PPROM, preterm premature rupture of membrane, GA, gestational age; LDH, lactate dehydrogenase