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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Nature. 2013 Oct 2;502(7471):368–371. doi: 10.1038/nature12579

Figure 1. ESP22 is secreted into juvenile tear fluid.

Figure 1

a, Strategy to identify mouse pheromones. b, Age-dependent gene expression in lacrimal gland (LG) determined by qPCR (n=4–12, mean, ± s.e.m.). c, Esp22 expression in juvenile and adult tissues determined by RT-PCR; olfactory epithelium (OE), olfactory bulb (OB), harderian gland (HG), submaxillary gland (SMG), parotid gland (PG), sublingual gland (SLG). d, Age- and sex-dependent Esp expression in LG determined by in situ hybridization. Scale bar, 100 µm. e, Western blot analysis of tears using anti-ESP22 antibody. f, MS analysis of an ESP22-derived tryptic peptide (GIVFNTIK) from tears.

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