Table 1.
Prognostic Schemes for Differentiated Thyroid Cancer
| Prognostic Variable | EORTC (1979) | AGES (1987) | AMES (1988) | MACIS (1993) | OSU (1994) | MSKCC (1995) | NTCTCS (1998) | Clinical Class (1990) |
|---|---|---|---|---|---|---|---|---|
| Patient Factors | ||||||||
| Age | X | X | X | X | - | X | X | |
| Sex | X | - | X | - | - | - | - | |
| Tumor Factors | ||||||||
| Size | - | X | X | X | X | X | X | |
| Multicentricity | - | X | - | - | X | - | X | |
| Grade | - | X | - | - | - | X | - | |
| Histology | X | Y | X | Y | - | X | X | X |
| ETE | X | X | X | X | X | X | X | |
| + LNs | - | - | - | - | X | X | X | X |
| Distant mets | X | X | X | X | X | X | X | X |
| Operative Factors | ||||||||
| Incomplete Resection | - | - | - | X | - | - | - | |
X = variable used in staging system
Y = variable used in staging system designed for PTC only
- = variable not used in staging system
EORTC = European Organization for Research on Treatment of Cancer
AGES = patient age, histologic grade of the tumor, tumor extent (extrathyroidal extension), and size of primary tumor
AMES = patient age, presence of distant metastases, extent and size of primary tumor
MACIS = metastasis, patient age, completeness of resection, local invasion, and tumor size
OSU = Ohio State University
MSKCC = Memorial Sloan-Kettering Cancer Center
NTCTCS = National Thyroid Cancer Treatment Cooperative Study