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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Pharm Res. 2013 Jun 21;30(11):2843–2854. doi: 10.1007/s11095-013-1112-6

Figure 2.

Figure 2

The structure of the Protected Graft Copolymer (PGC) used for HBEGF consists of a backbone polymer (central line), protective PEG chains (parallel lines), and a binding region shown by the circled negative charges along the chondroitin chain with 16 available sites; the peptide or free drug (dark circles) is in equilibrium, favoring the loaded PGC. The PGC used for gastrin 17 has a hydrophobic core similar to that previously published (8) but with different backbone. The average hydrodynamic diameter of this PGC is 20nm.