Table V.

Blinded examination of the insulin-stained section of pancreas (mean number of islets with Insulin per section^a), Group (Gr) descriptions are in Table I. Groups that received EGFRA have significantly less insulin compared to the diabetic control.

Group	Gr 1	Gr 2	Gr 4	Gr 5	Gr 6	Gr 7
Insulin Islet Score a; 0–4, mean	4.0	3.0	2.50	3.73	3.70	3.6
SEM	0.0	0.24	0.19	0.12	0.24	0.21
p value versus Gr 2	0.0003	-----	0.1136	0.0111 b	0.0486 b	0.0703 c

^aThree sections per animal of at least 200um apart and 5 animals/group (15 sections) were stained with H&E and adjacent sections were stained for insulin. Insulin Scoring System: 0=no staining, 1=<50% β-cells staining in an individual islet, 2=50–75% β-cells staining, 3=75–90% β-cells staining, 4=>90% β-cells staining.

^bOmeprazole treatment and Omeprazole+PGC-HBEGF have significantly higher insulin scores compared to the Gr 2 control.

^cPower analysis of the difference between Gr 2 and Gr 7 of 0.6 (with average standard deviation of 0.8 (0.21SEM*15^1/2)) indicates that we need at least 30 sections to rule out lack of significance with power of 80% and we only analyzed 15 sections. In other words, treatment with additional gastrin may have reduced the insulin content of the islet β-cells contributing to loss of analytical resolution.