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. 2013 Oct 3;140(3):374–389. doi: 10.1111/imm.12150

Figure 8.

Figure 8

Ab63, N213 and N62 prolong survival of SchuS4-infected BALB/c mice and reduce blood bacterial burden in a mouse model of respiratory tularaemia. (a) Survival. Mice (four or five per group) were inoculated with 24 colony-forming units (CFU) of SchuS4 intranasally (i.n.; in one experiment) or 36 CFU of SchuS4 i.n. (in a separate experiment), and injected intraperitoneally (i.p.) with the indicated monoclonal antibody (mAb) dose or with PBS 2 hr post infection. P values for mAb-treated groups compared with PBS-treated groups are indicated. (b) Blood bacterial burden. Mice were inoculated i.n. with 164 CFU of SchuS4 (left panel) or 109 CFU of SchuS4 (right panel), 2 hr post infection they were injected i.p. with 50 μg of the indicated mAbs or with PBS, then 3 days later they were bled and killed for blood CFU determination. Per cent CFU reduction compared with PBS was calculated from the median CFU numbers and the P-value was determined using the two-tailed Mann–Whitney U-test. The specificity of mAbs for terminal (T) or internal (I) O-antigen (OAg) epitope and their isotype are indicated.