Table 1.
I (pA): ± 40 mV | I (pA): −10 mV | |
---|---|---|
NT | 3430 ± 186 (30) | 793 ± 92 (30) |
GFP alone | 3019 ± 225 (8) | 800 ± 116 (9) |
GFP control (NT) | 3312 ± 456 (8) | 763 ± 57 (8) |
Kv2.1 DN | 2177 ± 173 (30)* | 438 ± 35 (30)* |
Kv2.1WT | 11000 ± 1268 (11)* | 2420 ± 435 (11)* |
WT control (NT) | 2778 ± 270 (11) | 847 ± 308 (11) |
All measurements were made at 200 ms after the beginning of the voltage step. Holding potential was –78 mV. Data are presented as mean ± SEM (number of cells). Transfected cells were paired with a non-transfected control cell selected in the same layer in the same slice, within ∼50 μm. NT = non-transfected control cells for Kv2.1 DN experiments. Kv2.1 DN = Kv2.1 pore mutant dominant negative construct. GFP control (NT) = non-transfected cells paired with GFP alone cells. Kv2.1 WT = wild-type Kv2.1 (overexpression). WT control (NT) = non-transfected cells paired with Kv2.1 WT overexpression group. *Significant difference from control (P < 0.05).