Table 2.

A: Diagnostic test characteristics of IL-27 at different cut points in all sepsis patients.
Cut point (≥)	Sensitivity	Specificity	PPV	NPV	+LR	−LR
1 ng/ml	88% (81 – 92)	23% (16 – 32)	57% (50 – 63)	62% (46 – 75)	1.1 (1.0 – 1.3)	0.5 (0.3 – 0.9)
2 ng/ml	63% (54 – 71)	62% (52 – 70)	65% (57 – 73)	59% (50 – 67)	1.6 (1.3 – 2.1)	0.6 (0.5 – 0.8)
3 ng/ml	43% (35 – 52)	86% (79 – 92)	79% (68 – 87)	57% (49 – 64)	3.2 (2.0 – 5.2)	0.7 (0.6 – 0.8)
4 ng/ml	33% (26 – 41)	92% (85 – 96)	83% (70 – 91)	54% (47 – 61)	4.1 (2.2 – 7.8)	0.7 (0.6 – 0.8)
5 ng/ml	26% (19 – 34)	96% (90 – 99)	88% (74 – 96)	53% (46 – 59)	6.6 (2.7 – 16.1)	0.8 (0.7 – 0.8)

B: Diagnostic test characteristics of PCT at different cut points in all sepsis patients.
Cut point (≥)	Sensitivity	Specificity	PPV	NPV	+LR	−LR
0.5 ng/ml	88% (82 – 93)	64% (55 – 72)	74% (67 – 80)	82% (73 – 89)	2.5 (1.9 – 3.1)	0.2 (0.1 – 0.3)
1 ng/ml	80% (72 – 86)	74% (66 – 82)	78% (71 – 85)	76% (68 – 83)	3.1 (2.3 – 4.3)	0.3 (0.2 – 0.4)
2 ng/ml	67% (59 – 74)	86% (79 – 92)	85% (77 – 91)	69% (61 – 76)	4.9 (3.1 – 7.8)	0.4 (0.3 – 0.5)
3 ng/ml	60% (52 – 68)	90% (83 – 94)	87% (78 – 93)	66% (58 – 73)	5.8 (3.4 – 9.8)	0.4 (0.4 – 0.5)
4 ng/ml	57% (49 – 65)	92% (85 – 96)	89% (81 – 94)	65% (57 – 72)	7.2 (3.9 – 13.2)	0.5 (0.4 – 0.6)