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. 2013 Jul 30;8(10):2145–2150. doi: 10.1021/cb400430t

Figure 3.

Figure 3

Combinatorial Screening of DDR1-IN-1/2 with the LINCS library against the SNU-1040 cell line. (A) Positive hits with DDR1-IN-1. CSF1R/DDR1/EGFR/TIE1/PDGFR2 = WZ-4-145; mTOR = WYE-125132; Cdk1/CyclinB = CGP60474; Chk = PF477736; PI3K = PI103; PI3K/mTOR = GSK2126458; Src/BCR-ABL = AP24534; EGFR = EKB-569; mTOR = Torin2. (B) Positive hits with DDR1-IN-2. CSF1R/DDR1/EGFR/TIE1/PDGFR2 = WZ-4-145; mTOR = WYE-125132; CLK2/CNSK1E/FLT3/ULK1 = WZ3105; Akt1 = A443644; LRRK2 = XMD11-50; mTOR = AZD8055; c-MET = ARQ197; CDK = BMS-387032; PI3K = GSK1059615; PLK1 = GW843682; MEK = AZD6244; mTOR = Torin2. (C) Combinatorial effect of DDR1-IN-1 with GSK2126458. (D) Synergistic effect of DDR1-IN-2 with AZD8055. (E) Combinatorial effect on the blockade of signaling pathway factors.