Table 2.

Multivariable logistic regression models demonstrating adjusted odds ratio for development of acute respiratory distress syndrome.

Complete Model (N=778)	Adjusted Odds Ratio (95% CI)	p-value
Initial Serum Lactate Strata
Low	Reference	Reference
Intermediate	3.76 (1.06 – 13.31)	0.04
High	6.42 (1.86 – 22.23)	0.003
APACHE II (baseline) *	1.06 (1.01 – 1.11)	0.02
Diabetes mellitus	0.31 (0.13 – 0.77)	0.01
Pulmonary source of sepsis	3.97 (2.06 – 7.67)	<0.001
Microbiologically-proven infection	2.47 (1.20 – 5.08)	0.01
Shock at presentation	1.74 (0.87 – 3.49)	0.12
Transfusion at presentation	1.70 (0.69 – 4.21)	0.25

Definition of abbreviation: APACHE=Acute physiology and chronic health evaluation score; CI=confidence interval.

An adjusted odds ratio of greater than 1 indicates that the factor is associated with greater odds of developing ARDS. The following variables did not alter the odds ratio estimates of the candidate risk factors significantly, nor were they significantly associated with ARDS development: serum creatinine, platelet count, chronic renal insufficiency, human immunodeficiency virus, urosepsis, soft-tissue infection, or admission type (medical vs. surgical).

^*Odds ratio for each 1-unit increase in baseline APACHE II score.