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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Hepatology. 2013 Sep 30;58(5):1713–1723. doi: 10.1002/hep.26554

Figure 4. Rac-1 activity is cAMP/PKA-dependent in Pkhd1del4/del4 cholangiocytes.

Figure 4

Rac-1 (A), Cdc42 (B) and RhoA (C) activities were measured by an ELISA that recognized the activated forms. All the three Rho GTPases were activated by forskolin (F) and inhibited by the PKA inhibitor, PKI, in Pkhd1del4/del4 cholangiocytes but not in WT. However, the effects on Rac-1 were significantly higher and with a different kinetic with respect to Cdc42 and RhoA. (n=8; *p<0.05 vs untreated cells (C); ○p<0.05 vs forskolin).