Simulations of the directional variance of the diffusion encoding scheme of the MEDITATE sequence (2 series of 13 echoes): 95% confidence angles or cone of uncertainty [47] a) averaged over all tensor orientations as a function of measurement SNR and FA; b,c,d) as a function of the azimuth and elevation angles (θ and φ) of the tensor (FA = 0.9, MD = 1.5 10−9 m2/s) in surface (c, SNR = 29) and polar plots (b,d). 95% cones of uncertainty are taken as the 95% percentile over 5000 samples for each tensor orientation.