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Folate and methionine pathway. DNMT DNA methyltransferase; MTHFR 5,10-methylenetetrahydrofolate reductase; 1 Methionine-synthase (vitamin B12 and zinc dependent); 2 Betaine-homocysteine-methyltransferase (zinc dependent); 3 Methionine-adenosyltransferase; 4 S-adenosylhomocysteine hydrolase. Adapted from Ebisch et al. [7]
