Table 2.

Percentage of methylation of each analyzed CpG at the H19-ICR locus in the six infertile patients showing the most severe pattern of hypomethylation

Case	CpG 1	CpG 2	CpG 3	CpG 4	CpG 6	CpG 7	CpG 8	CpG 9	CpG 10	CpG 11	CpG 12	CpG 13	CpG 14
37	84	84	78	67	77	85	82	83	74	82	79	89	80
50	83	84	74	71	73	81	80	83	74	76	75	85	83
80	86	92	85	56	82	88	79	81	83	84	73	84	88
91	83	88	81	70	74	90	87	84	74	81	73	88	80
95	9	8	11	10	10	8	7	8	7	11	10	10	12
102	70	73	68	64	66	74	71	75	67	74	70	78	76
Reference range	86–96	87–97	84–93	61–88	82–88	83–100	85–97	85–97	74–92	83–92	73–95	89–99	84–96

Hypomethylated CpGs are indicated in bold. All patients showed hypomethylation affecting more than 50 % of the CpGs