Table 1.
Anticonvulsant activity of the tested compounds.
| Drug/test compound | Dose mg/Kg |
No. of mice |
No. of mice protected |
Protection % |
ED50% mg/kg |
Mol. Wt. | ED50% mmol/kg |
Relative potency to phenobarbitone sodium |
|---|---|---|---|---|---|---|---|---|
| Phenobarbitone sodium | 6.25 12.5 25 |
6 6 6 |
1 3 6 |
16.66 50 100 |
12.5 | 254 | 0.049 | 1.00 |
| 8a | 20 40 80 |
6 6 6 |
0 3 5 |
0 50 66.66 |
40 | 335 | 0.119 | 0.41 |
| 9e | 20 40 80 |
6 6 6 |
1 3 5 |
16.66 50 83.33 |
40 | 316 | 0.126 | 0.38 |
| 10 | 20 40 80 |
6 6 6 |
1 2 3 |
16.66 33.33 50 |
80 | 274 | 0.291 | 0.16 |
| 12 | 20 40 80 |
6 6 6 |
1 3 5 |
16.66 50 83.33 |
40 | 340 | 0.117 | 0.41 |
| 14 | 20 40 80 |
6 6 6 |
2 4 5 |
33.33 66.66 83.33 |
30 | 399 | 0.075 | 0.65 |
| 15a | 20 40 80 |
6 6 6 |
2 4 5 |
33.33 66.66 83.33 |
30 | 361 | 0.083 | 0.58 |
| 15b | 20 40 80 |
6 6 6 |
2 4 5 |
33.33 66.66 84.33 |
30 | 409 | 0.073 | 0.66 |
| 16 | 20 40 80 |
6 6 6 |
2 4 5 |
33.33 66.66 83.33 |
30 | 316 | 0.094 | 0.51 |
| 17a | 20 40 80 |
6 6 6 |
0 3 5 |
0 50 66.66 |
40 | 362 | 0.110 | 0.44 |
| 17d | 20 40 80 |
6 6 6 |
1 3 5 |
16.66 50 66.66 |
40 | 378 | 0.105 | 0.46 |
| 17e | 20 40 80 |
6 6 6 |
0 1 3 |
0 16.66 50 |
80 | 396 | 0.202 | 0.24 |