Table 1.
Analyzed compounds
| Drug Class | Compound | Calibration curve range (µg/mL) |
Published Drug Concentrations (µg/mL) |
Regression Equation | R2 |
|---|---|---|---|---|---|
| Anticoagulants | Acetylsalicylic acid/salicylic acid | 0.1–50 | 44–330 [27] | =0.96x−37.70 | 0.97 |
| Clopidogrel | 0.0002–0.1 | 0.0145 [30] | =42.53x−2.53 | 0.98 | |
| Warfarin | 0.1–50 | 3.1 [27] | =−0.003x2+300.08x+40934.95 | 0.97 | |
| Angiotensin converting enzyme inhibitors | Captopril | 0.005–2.5 | 0.82–0.88 [27] | =113.88x−578.64 | 0.95 |
| Enalapril | 0.001–0.5 | 0.045–0.07 [27] | =1652.23x −1455.89 | 0.99 | |
| Enalaprilat | 0.001–0.5 | 0.045–0.07 [27] | =415.28x−304.59 | 0.93 | |
| Lisinopril | 0.001–0.5 | 0.082 [27] | =69.73x−95.16 | 0.94 | |
| Ramipril | 0.001–0.5 | 0.023 [37] | =2196.82x−2230.51 | 0.98 | |
| Losartan | 0.0005–0.25 | 0.0845–1.3949 [20] | =557.90x−95.55 | 0.91 | |
| Losartan | 0.0005–0.25 | 0.0845–1.3949 [20] | =557.90x−95.55 | 0.91 | |
| Angiotensin II receptor blockers | Telmisartan Valsartan | 0.001–0.5 | 0.084±0.029 [25] | =200.57x−43.99 | 0.97 |
| 2.22±1.622 [25] | =178.88x−198.07 | 0.97 | |||
| Beta blockers | Atenolol | 0.01–5 | 1.48–2.75 [27] | =157.53x+729.22 | 0.97 |
| Carvedilol | 0.001–0.5 | 0.0265–.205 [17] | =426.37x+142.57 | 0.98 | |
| Metoprolol | 0.001–0.5 | 116 [27] | =201.61x−26.52 | 0.96 | |
| Propranolol | 0.001–0.5 | 335 [27] | =306.89x−65.16 | 0.96 | |
| Amlodipine | 0.0005–0.25 | 0.024 [27] | =456.72x−227.47 | 0.99 | |
| Diltiazem | 0.001–0.5 | 0.1–0.2 [27] | =2463.22x − 1740.23 | 0.99 | |
| Nifedipine | 0.001–0.5 | 0.115 [27] | =281.82x+26.31 | 0.95 | |
| Verapamil | 0.001–0.5 | 355 [27] | =2035.92x−827.44 | 0.99 | |
| Diuretics | Canrenone (Spironolactone) | 0.005–2.5 | 0.1–0.5 [26] | =43.77x+28.69 | 0.96 |
| Furosemide | 0.005–2.5 | 1–2 [19] | =10.79x−12.37 | 0.97 | |
| Hydrochlorothiazide | 0.005–2.5 | 0.202 [27] | =3.40x+20.58 | 0.98 | |
| Triamterene | 0.0002–0.1 | 0.0157–0.0446 [24] | =232.95x+0.37 | 0.97 | |
| Statins | Atorvastatin | 0.0001–0.05 | 0.0054–0.0078 [16] | =179.89x−25.49 | 0.90 |
| Lovastatin | 0.0002–0.1 | 0.00977 [21] | =53.06x+1.38 | 0.97 | |
| Pravastatin | 0.002–1 | 0.0274±0.0107 [22] | =4.37x+1.15 | 0.97 | |
| Simvastatin | 0.001–0.5 | 0.0073–0.0285 [23] | =29.37x−12.85 | 0.96 | |
| Vasodilators | Hydralazine | 0.01–5 | 0.3–0.5 [27] | =211.23x−4261.64 | 0.99 |
| Isosorbide | 0.001–0.5 | 0.0258 [27] | =11.45x+65 | 0.96 | |
| Methyldopa | 0.01–5 | 2.2 [27] | =120.39x−936.79 | 0.96 | |
| Other | Aliskiren | 0.001–0.5 | 0.2–0.4 [29] | =92.89x−152.09 | 0.97 |
| Clonidine | 0.0001–0.05 | 0.0013 [27] | =140.04x+7.57 | 0.95 | |
| Digoxin | 0.0001–0.05 | 0.0014 [27] | =19.63x−1.08 | 0.99 | |
| Fenofibrate/ic acid | 0.1–50 | 5–15 [18] | =−0.001x2+170.76x+11465.34 | 0.95 | |
| Niacin | 0.0002–0.1 | 0.0182–0.109 [21] | =46.28x+9.09 | 0.97 |