Table 4.
Independent risk factors for development of NODAT for all DDLT recipients (n = 19, 582).
| Variable | Univariate HR (95% CI) |
P value | Multivariate HR (95% CI) |
P value | |
|---|---|---|---|---|---|
| Recipient age | >50 versus ≤50 | 1.27 (1.20–1.35) | <0.0001 | 1.14 (1.06–1.22) | 0.0003 |
|
| |||||
| Recipient gender | Male versus female | 1.16 (1.10–1.23) | <0.0001 | 1.13 (1.06–1.21) | 0.0002 |
|
| |||||
| Recipient race | AA versus others | 1.20 (1.03–1.39) | 0.0019 | 1.09 (0.93–1.28) | 0.2994 |
| Caucasian versus others | 1.05 (0.93–1.20) | 0.4128 | 0.95 (0.83–1.09) | 0.4842 | |
| Hispanic versus others | 1.17 (1.01–1.35) | 0.033 | 1.05 (0.90–1.22) | 0.540 | |
|
| |||||
| Recipient BMI | >30 versus ≤25 | 1.32 (1.23–1.42) | <0.0001 | 1.26 (1.16–1.35) | <0.0001 |
| 25–30 versus ≤25 | 1.17 (1.10–1.26) | <0.0001 | 1.14 (1.06–1.23) | 0.0004 | |
|
| |||||
| Donor age | ≥60 versus <60 | 1.26 (1.18–1.35) | <0.0001 | 1.21 (1.12–1.30) | <0.0001 |
| Etiology of liver disease | ALD versus others | 1.26 (1.14–1.39) | <0.0001 | 1.22 (1.10–1.36) | 0.0002 |
| HCV versus others | 1.37 (1.28–1.48) | <0.0001 | 1.34 (1.24–1.46) | <0.0001 | |
| NASH + cryptogenic cirrhosis versus others | 1.53 (1.37–1.70) | <0.0001 | 1.45 (1.29–1.63) | <0.0001 | |
|
| |||||
| Rejection | Treated rejection versus no rejection | 3.31 (3.02–3.62) | <0.0001 | 3.51 (3.20–3.84) | <0.0001 |
|
| |||||
| Donor history of diabetes | Yes versus no | 1.18 (1.08–1.30) | 0.0002 | 1.20 (1.10–1.31) | 0.0001 |
DDLT: deceased donor liver transplant; AA: African American; BMI: body mass index; ALD: alcohol liver disease; HCV: hepatitis C virus; NASH: nonalcoholic steatohepatitis; HR: hazard ratio; CI: confidence interval.