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. Author manuscript; available in PMC: 2013 Oct 20.
Published in final edited form as: Gene. 2005 Jul 18;354:132–139. doi: 10.1016/j.gene.2005.03.028

Fig. 2.

Fig. 2

Resistance to etoposide-mediated apoptosis in mtDNA-depleted C2C12 cells. Control (A and C), and mtDNA-depleted (B and D) cells were subjected to apoptosis assay before (A and B) or after treatment with 25 µM etoposide for 4 h to induce apoptosis. The extent of nuclear DNA breaks was measured by TUNEL assay with anti Digoxigenin peroxidase ApopTag Peroxidase system as described in the Materials and methods section.