Table 1.
Effect of Treatments on Mean LH Concentrations
| Treatment | Control |
Agonist/Antagonist |
||||
|---|---|---|---|---|---|---|
| Before | After 0–2 Hours | After 2–4 Hours | Before | After 0–2 Hours | After 2–4 Hours | |
| p271 microimplant | 8.4 ± 1.5 | 6.6 ± 0.9 | 4.8 ± 0.4a | 6.8 ± 1.5 | 5.7 ± 1.0 | 3.1 ± 0.7a |
| p271 2 nmol | 8.5 ± 2.3 | 9.0 ± 1.4 | 9.8 ± 2.1 | 9.8 ± 1.4 | 9.7 ± 1.6 | 10.1 ± 0.9 |
| SB222200 | 13.2 ± 2.4 | 13.7 ± 3.9 | 12.3 ± 3.8 | 12.5 ± 1.3 | 11.9 ± 2.3 | 9.1 ± 2.3a |
| NKB | 9.1 ± 1.5 | 9.7 ± 1.0 | 8.9 ± 1.4 | 10.5 ± 0.8 | 11.5 ± 1.4 | 9.6 ± 1.6 |
| BNI | 7.6 ± 1.1 | 9.0 ± 1.4 | 8.3 ± 1.0 | 8.1 ± 1.1 | 10.3 ± 1.3 | 9.8 ± 1.6 |
| MK-801 | 6.6 ± 1.4 | 9.0 ± 2.6 | 8.2 ± 1.7 | 7.3 ± 1.5 | 9.6 ± 2.1 | 9.9 ± 2.4 |
| Acyline | 6.6 ± 1.4 | 9.0 ± 2.6 | 8.2 ± 1.7 | 6.1 ± 1.0 | 7.7 ± 2.3 | 7.4 ± 0.2 |
| UFP101 | 10.9 ± 2.1 | 11.5 ± 1.4 | 11.2 ± 1.3 | 10.3 ± 1.0 | 12.1 ± 1.3 | 11.9 ± 1.3 |
Data presented are mean (±SEM) for time periods before and 0–2 and 2–4 hours after start of treatments. All treatments were via microimplants, except for 2 nmol of p271, which were administered by microinjections.
a
P < .05 vs control (before treatment) values by two-way ANOVA.