Figure 1.

Doxorubicin induces resistin in humanized resistin mice (Hum-Retn) not in WT. A, Doxorubicin at (dox) 25 mg/kg ip induced serum human resistin in 10- to 12-week-old male Hum-Retn mice compared with vehicle (veh) at day 5. B, Murine resistin was not induced by doxorubicin in WT C57Bl6 mice. C, Serum LDH activity was induced significantly by doxorubicin in Hum-Retn mice only. D, Serum TNFα was elevated significantly in Hum-Retn and WT but not RKO. Mean + SEM, n = 5–12 for all groups; ‡, P < .05 doxorubicin vs vehicle of same animal type. ns, not significant.