Figure 1.

Total distance traveled (cm) by male and female mice in automated photobeam cages at the start of CP55,940 (CP) treatment at 6 weeks of age, end of CP treatment at 9 weeks of age and 2 weeks after treatment had ceased. Wild-type and HET mice were either treated with vehicle solution or CP from 6 to 9 weeks of age. CP treatment significantly reduced distance traveled in the first and second session in both sexes and distance traveled was still slightly, but significantly reduced in male mice 2 weeks after treatment had ceased (for statistical analysis see text). Additional effects between groups of animals analyzed with pairwise comparison are indicated in the figure: ^*P < 0.05 for differences between vehicle-treated controls and CP-treated mice based on main effect of CP in ANOVA. ^$P < 0.05 for difference between genotypes based on pair-wise post-hoc ANOVAs.