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. 2013 Oct 21;7:149. doi: 10.3389/fnbeh.2013.00149

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Copyright © 2013 Klug and van den Buuse.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Average percentage PPI in the four treatment groups: WT/veh, WT/CP, HET/veh, and HET/CP in both sexes. All groups were administered saline (Sal; open bars) and 0.4 mg/kg CP55,940 (CP; black bars) before the PPI test. HET mice had significantly lower PPI after saline injection compared to wild-type controls. Acute CP treatment increased PPI in male “two hit” mice and in all female groups. ^*P < 0.05 for difference with acute saline based on genotype × acute treatment interaction and post-hoc comparisons (males) or main ANOVA effect (females). ^**P < 0.05 for difference between HET mice and wild-type controls based on ANOVA main effect.