Table 1.
Bodyweight (grams) of wild-type (WT) and BDNF heterozygous (HET) mice treated with vehicle (veh) or CP55,940 (CP) at 6 weeks (beginning of drug treatment), 9 weeks (end of drug treatment), and 12 weeks of age (during behavioral testing).
| WT/veh | WT/CP | HET/veh | HET/CP | |
|---|---|---|---|---|
| MALE MICE | ||||
| Week 6 | 21.4 ± 0.4 | 20.7 ± 0.5 | 21.9 ± 0.3 | 21.9 ± 0.5 |
| Week 9 | 24.3 ± 0.5 | 22.7 ± 0.3 | 25.3 ± 0.4 | 24.1 ± 0.4 |
| Week 12 | 26.4 ± 0.7 | 26.0 ± 0.5 | 28.6 ± 0.5 | 27.7 ± 0.6 |
| FEMALE MICE | ||||
| Week 6 | 16.6 ± 0.5 | 16.8 ± 0.2 | 18.5 ± 0.4 | 17.9 ± 0.6 |
| Week 9 | 18.2 ± 0.4 | 17.9 ± 0.2 | 21.0 ± 0.6 | 19.8 ± 0.4 |
| Week 12 | 19.7 ± 0.5 | 20.0 ± 0.3 | 24.7 ± 1.0 | 23.1 ± 0.6 |
Data are mean ± standard error of the mean (SEM) of 10–16 animals per group. At all ages, male mice weighed significantly more than female mice and HET mice weighed more than their wild-type littermates. For further details on statistical analysis, see text.