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. 2013 Oct 21;7:58. doi: 10.3389/fnsys.2013.00058

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Copyright © 2013 Fitch, Alexander and Threlkeld.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean difference in percent attenuation as compared to matched shams on a rapid acoustic processing discrimination task. Behavioral measures were obtained in juvenile (about P30) and adult (about P60) rats (repeated testing, same subjects). (A) Subjects with lesions induced on P1 and P3 showed cortical microgyric malformations in post mortem analysis. Subjects with P5 lesions showed only glial scarring. All subjects showed deficits relative to matched shams in juvenile testing. In adulthood, only P1 lesioned (microgyric) subjects were significantly impaired as compared to shams. Data adapted from Threlkeld et al. (2006). (B) For subjects with HI induced on P1 and P7, both groups again showed deficits in the juvenile period, but only P7 HI remained impaired relative to matched shams in adulthood. Data adapted from McClure et al. (2006).