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Model for Arf6 regulation of the WAVE regulatory complex. Arf6 GEFs such as EFA6 or BRAG activate Arf6. ARNO resides in a soluble autoinhibited conformation, and is recruited to the plasma membrane and activated by Arf6 binding of the ARNO PH domain. ARNO activates Arf1 that collaborates with Rac1 to drive WRC-dependent actin polymerization.
