Skip to main content
. 2013 Oct 21;3:2992. doi: 10.1038/srep02992

Figure 1. The response to cetuximab treatment and genetic profile of GC-PDX models.

Figure 1

Panel A: The PDX-GC models are sorted by the tumor response to cetuximab (ΔT/ΔC). The responders at the right part display higher EGFR mRNA level and IHC staining intensity, and the only two cases (GA0075 and GA0152, CN > 5) of gene amplification. Panel B: The representative images of responders and non-responders. The responders GA0152 and GA0075 display IHC score 3+, and gene amplification (GA0075, CN = 5.8; GA0152, CN > 15), while non-responders GA0119 and GA0139 are with IHC low expression and no gene amplification. Left: Representative tumor growth curves of responders and non-responders. Middle: IHC analysis of tumor models; Right: Dual-color FISH assay in gastric carcinoma. Probe for EGFR locus is labeled in red and CEP7 labeled in green. Blue: Nuclei.