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. 2013 Oct 21;3:2996. doi: 10.1038/srep02996

Figure 6. Newly generated hair cells induced by co-expression of Pax2 and Math1 acquired certain function.

Figure 6

(A and B) Triple immunofluorescence of BrdU, Pax2, and myosin VIIA showed that the newly generated hair cells originated from transfection positive cells. Arrows pointed to BrdU+/myosin VIIA+/Pax2+ cells. (C) Double immunofluorescence of BrdU and FM1-43 suggested that newly generated hair cells developed mechanotransduction channels and acquired certain function. Arrow pointed to BrdU+/FM1-43+ cell. Data in (D) showed the number of BrdU+/FM1-43+ cells in the HCR and LER at 2 weeks after adenovirus incubation. (E) Triple immunofluorescence of BrdU, myosin VIIA, and FM1-43 confirmed that the newly generated hair cells acquired certain function. Arrow pointed to BrdU+/myosin VIIA+/FM1-43+ cell. Scale bars: 5 μm in (A and C); 10 μm in (B and E).