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Scaled functional sensitivity w as a function of scaled total CD8 density xT. (A) Curves for various values of the scaled TCR/pMHCI off-rate α. (B) Curves for various values of the factor γR by which CD8 modulates the TCR triggering threshold. Parameter values in (A,B): δ = 2.5, ν = 0.05, n = 100, γkin = 0.5, γoff = 0.5, γR = 0.5, κ = 1, mT = 10, rT = 10, α = 1.
