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Scaled functional sensitivity w as a function of scaled total CD8 density xT. (A) Curves for various values of the scaled TCR/pMHCI off-rate α. (B) Curves for various values of the dimensionless factor γoff expressing the modulatory effect of CD8 on the TCR/pMHCI off-rate. Parameter values in (A,B) δ = 3, ν = 300, n = 100, γkin = 0.05, γoff = 0.2, γR = 0.5, κ = 2, mT = 10, rT = 10, α = 2.
