Figure 5.

(A) Scaled functional sensitivity w as a function of scaled TCR/pMHCI off-rate α. (B) Degeneracy curves ℙ(w > ω) for HLA A^∗0201 mutants with altered binding affinity for CD8: A245V (dotted line), wild-type (semi-dashed line), Q115E (dashed line), and A2/α3k^b (solid line). The three regions represent the overall pattern of CD8⁺ T-cell antigen specificity and the arrow indicates the strength of pMHCI/CD8 interaction. (C) Degeneracy curves ℙ(w > ω) for HLA A^∗0201 mutants with altered binding affinity for CD8. The parameter values are the same as in A except for ν = 10. Parameter values in (A,B): δ = 0.2, ν = 0.05, n = 100, γ_kin = 0.5, γ_off = 0.5, γ_R = 0.2, κ = 1, m_T = 10, r_T = 10, x_T = 10. The log-normal distribution has mean 5 and SD 0.5.