Table 2.

Dimensionless (scaled) parameters that govern functional sensitivity.

mT	Scaled total pMHCI density
xT	Scaled total CD8 density
rT	Scaled total TCR density
α	Scaled TCR/pMHCI off-rate without CD8 bound
δ	Scaled pMHCI/CD8 off-rate with TCR bound
ν	Scaled kinetic effect of pMHCI/CD8 interactions with and without TCR
κ	Ratio of dissociation constants K1 and K3
γoff	Factor by which CD8 modulates TCR/pMHCI off-rate
γkin	Factor by which CD8 modulates the TCR/pMHCI affinity
γR	Factor by which CD8 modulates the TCR triggering threshold