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. Author manuscript; available in PMC: 2013 Oct 21.
Published in final edited form as: Brain Res. 2009 Jan 30;1265:138–147. doi: 10.1016/j.brainres.2009.01.033

Fig. 3. Effect of Rac1 AS-ODNs (AS) or missense oligonuleotides (MS) on Rac1 expression and activation or MLK3/Rac1/POSH complex formation in CA1 region at 30 min of reperfusion following cerebral ischemia.

Fig. 3

(A,B) The AS-ODNs administration significantly attenuated cerebral ischemia-induced Rac1 expression and activation at 30 min after ischemia. Missense ODNs (MS) had no significant effect on Rac1 expression or activation in CA1 as compared to Vehicle control. (C,D) Homogenates from the hippocampal CA1 region at 30 min of reperfusion were immunoprecipitated with anti-MLK3 antibody, and then separately blotted with anti-Rac1 or POSH antibody. (B,D) Bands on western blots were scanned and the intensities were expressed as folds versus sham treatment. Data are means ± SD from four independent animals (n = 4). *p < 0.05 versus sham group. # p < 0.05 versus MS group.