Table 2.
Change in birth weight (g) associated with in cord blood bulky DNA adduct levels.
| Variable | n | β (95% CI) | p-Value |
|---|---|---|---|
| Basic adjusteda | |||
| Adducts (increase of 10 adducts/108 nt) | 612 | –30 (–62, 2) | 0.07 |
| Low (< 5.9/108 nt)b | 205 | Reference | |
| Middle (5.9–12.4/108 nt) | 203 | –47 (–128, 35) | 0.26 |
| High (> 12.4/108 nt) | 204 | –110 (–192, –28) | 0.009 |
| Further adjustedc | |||
| Adducts (increase of 10 adducts/108 nt) | 409 | –21 (–62, 21) | 0.32 |
| Low (< 5.9/108 nt)d | 153 | Reference | |
| Middle (5.9–12.4/108 nt) | 140 | –51 (–146, 43) | 0.29 |
| High (> 12.4/108 nt) | 116 | –129 (–233, –25) | 0.015 |
| aEffect estimates on birth weight (g) in linear regression models adjusted for gestational age, infant sex, maternal active smoking at the end of pregnancy, and country (random effect). bThe mean birth weight of the reference group was 3,510 g. cFurther adjusted for maternal ethnicity, maternal prepregnancy BMI, parity, maternal age, maternal exposure to SHS, mode of delivery, maternal education, maternal consumption of fruits and vegetables, and season of delivery. dThe mean birth weight of the reference group was 3,559 g. | |||