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IFNγ synergize H. pylori-mediated B7-H2 downregulation on gastric epithelium. N87 cells were treated with IFNγ (100 U/mL) for 48 hour. Cells treated with IFNγ were washed and cultured with medium for 24 hour before they were either infected with H. pylori 51B WT and cagA− strain in the presence or absence of IFNγ-neutralizing Ab. B7-H2 expression on N87 GEC was measured by flow cytometry after 24 hour. Graph represents the mean ± SD (n=8); P < .05.
