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. 2013 Aug 23;32(20):2672–2684. doi: 10.1038/emboj.2013.188

Figure 2.

Figure 2

treRNA promotes migration and invasion in vitro and metastasis in vivo. (A, B) Quantitative analysis of MCF7 cells expressing a vector control, treRNA, or control long non-coding RNA HAR1A in migration (A) and invasion (B) assays. Data represent mean and s.d. (triplicates). (C) Transplantation of MCF7 cells expressing luciferase and treRNA in mouse mammary fat pads led to lung metastasis. Transplantation of MCF7 cells expressing a vector control does not lead to metastasis. (D) Knockdown of endogenous treRNA suppressed lung metastasis in vivo. A549 cells expressing luciferase and two different treRNA siRNAs or a control siRNA were transplanted into mice via tail vein injection. Lung metastasis was significantly reduced in A549 cells with treRNA knockdown. The data were collected from three independent experiments and presented as mean±s.d.