Table 6.
Associations between serum PFOA and PFOS and birth weight in full-term infants.
| PFC metric | Crude ∆ grams All births n= 1,470 | Adjusteda∆ grams (95% CI) All births n = 1,470 | Adjusteda∆ grams (95% CI) First prospectivebn = 710 |
|---|---|---|---|
| PFOA | |||
| Per in unit increase | –9 | –8 (–28, 12) | 5 (–22, 33) |
| Per IQR increasec | –5 | –5 (–13, 2) | 1 (–10, 11) |
| Quintile (ng/mL) | p-trend= 0.701 | p-trend= 0.622 | |
| 0 to < 6.9 | 0 (reference) | 0 (reference) | 0 (reference) |
| 6.9 to < 11.1 | 21 | 35 (–33, 105) | 135 (34, 236) |
| 11.1 to < 18.9 | –35 | –9 (–79, 61) | 26 (–71, 124) |
| 18.9 to < 37.2 | –1 | 4 (–65, 72) | 56 (–37, 149) |
| ≥ 37.2 | –3 | 0 (–68, 69) | 74 (–20, 169) |
| PFOS | |||
| Per in unit increase | –18 | –29 (–66, 7) | –49 (–90, –8) |
| Per IQR increasec | –12 | –23 (–48, 3) | –29 (–58, 0) |
| Quintile (ng/mL) | p-trend= 0.045 | p-trend= 0.006 | |
| 0 to < 8.6 | 0 (reference) | 0 (reference) | 0 (reference) |
| 8.6 to < 12.1 | 0 | –25 (–96, 48) | –33 (–140, 74) |
| 12.1 to < 15.9 | –45 | –37 (–109, 35) | –115 (–216, –14) |
| 15.9 to < 21.4 | –76 | –83 (–152, –13) | –149 (–244, –54) |
| ≥ 21.4 | –14 | –54 (–124, 17) | –105 (–196, –13) |
| aAdjusted for maternal age, educational level (< 12 years, 12, 13–15, ≥ 16), smoking status (current, former, non), parity (0, ≥ 1), BMI (underweight, normal, overweight, obese), self-reported diabetes, time between conception and serum measurement (year strata), indicator variables for gestational week (37, 38, 39, 40, ≥ 41). bFirst pregnancy conceived after serum measurement among nonpregnant women. cUntransformed, IQR PFOS = 10 ng/mL, IQR PFOA = 22 ng/mL. | |||