Table 1.

The Quality of Evidence Utilizing the GRADE Approach are Defined

GRADE	Definition
High	Further research is very unlikely to change our confidence in the estimate of effect (all of the domains are met).
Moderate	Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate (one of the domains is not met).
Low	Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate (two of the domains are not met).
Very Low	We are very uncertain about the estimate (three or more of the domains are not met).