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Formation of eicosanoids and eicosanoid-derived GSH-adducts. Abbreviations: 5-HEDH, 5-hydroxyeicosanoid dehydrogenase; EH, epoxide hydrolase; FLAP, 5- lipoxygenase activating protein; FOG-7, 5-oxo-eicosatetraenoic acid GSH-adduct, LTAH, leukotriene A4 hydrolase; LTAS, leukotriene A4 synthase; PGS, prostaglandin synthase; TX, thromboxane; TXS, thromboxane synthase.
