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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Neurotoxicology. 2013 Jul 8;38:91–100. doi: 10.1016/j.neuro.2013.06.008

Fig. 5.

Fig. 5

Mercury species increase superoxide production at high concentrations. SH-SY5Y (A) and NPC (B) cells were incubated with toxicants for 5 h as previously described. Conversion of NBT to formazan by superoxide was determined by absorbance normalized to cell viability. Results are mean % change from vehicle control +/- SEM from 4 independent experiments. * = p < 0.05 significantly different from positive control by ANOVA w/Bonferroni's test. High doses of MeHg (< 3 μM) and HgCl2 (100 μM) lead to significant increases in NBT signal as did the positive control, menadione (25 μM). Superoxide production was not increased in the dose range of the enhanced STAT3 effect in either cell type.