Downregulation of FoxM1 decreased MMP-9 and VEGF activities. Effects of FoxM1 downregulation on the activities of MMP-9 and VEGF, as measured by respective ELISA analysis conducted using conditioned media. C, Control; D, DIM [25 or 40 (MDA-MB-231) μM]; T, Taxotere (1.0 nM); D+T, DIM + Taxotere. All the analyses were done at least thrice. *, p < 0.05; **, p < 0.01 relatively control.